Miguel López-Botet Selected Research

Neoplasms (Cancer)

1/2024	NK cell-triggered CCL5/IFNγ-CXCL9/10 axis underlies the clinical efficacy of neoadjuvant anti-HER2 antibodies in breast cancer.
12/2021	CD137 Costimulation Counteracts TGFβ Inhibition of NK-cell Antitumor Function.
10/2021	Reduced expansion of CD94/NKG2C+ NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions.
1/2020	Haplotype-Based Analysis of KIR-Gene Profiles in a South European Population-Distribution of Standard and Variant Haplotypes, and Identification of Novel Recombinant Structures.
1/2019	NK Cell Infiltrates and HLA Class I Expression in Primary HER2+ Breast Cancer Predict and Uncouple Pathological Response and Disease-free Survival.
1/2019	High Numbers of Circulating CD57+ NK Cells Associate with Resistance to HER2-Specific Therapeutic Antibodies in HER2+ Primary Breast Cancer.
4/2017	Targeting NK-cell checkpoints for cancer immunotherapy.
1/2017	Dual Role of Natural Killer Cells on Graft Rejection and Control of Cytomegalovirus Infection in Renal Transplantation.
1/2017	Interplay between Natural Killer Cells and Anti-HER2 Antibodies: Perspectives for Breast Cancer Immunotherapy.
4/2007	Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets.

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Miguel López-Botet Research Topics

Disease

18	Infections 05/2020 - 12/2004
10	Neoplasms (Cancer) 01/2024 - 04/2007
7	Cytomegalovirus Infections (Inclusion Disease) 10/2021 - 12/2004
5	Breast Neoplasms (Breast Cancer) 01/2024 - 01/2017
3	Inflammation (Inflammations) 12/2023 - 11/2013
3	Virus Diseases (Viral Diseases) 01/2019 - 05/2010
3	Leukemia 01/2007 - 04/2002
2	Lymphocytosis 10/2021 - 03/2011
2	Multiple Sclerosis 05/2020 - 11/2010
2	Pathologic Complete Response 01/2019 - 01/2019
2	Viremia 01/2017 - 03/2015
2	Lymphoma (Lymphomas) 07/2005 - 10/2003
1	Prolymphocytic Leukemia 01/2020
1	Proteinuria 01/2019
1	T-Cell Leukemia (Leukemia, T Cell) 01/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/2016
1	Stroke (Strokes) 11/2013
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2013
1	Atherosclerosis 10/2011
1	Vascular Diseases (Vascular Disease) 10/2011
1	Large Granular Lymphocytic Leukemia 03/2011
1	Carcinoma (Carcinomatosis) 05/2005
1	Myeloid Leukemia (Leukemia, Myelocytic) 12/2004

Drug/Important Bio-Agent (IBA)

7	Natural Killer Cell ReceptorsIBA 01/2017 - 12/2004
5	AntibodiesIBA 01/2024 - 10/2011
5	Biomarkers (Surrogate Marker)IBA 01/2024 - 10/2011
5	CytokinesIBA 05/2020 - 07/2005
5	NK Cell Lectin-Like Receptor Subfamily CIBA 03/2020 - 07/2006
4	Leukocyte Immunoglobulin-like Receptor B1IBA 01/2020 - 10/2011
4	KIR ReceptorsIBA 01/2020 - 12/2004
3	HLA Antigens (Human Leukocyte Antigens)IBA 12/2023 - 03/2011
3	Trastuzumab (Herceptin)FDA Link 12/2021 - 01/2017
3	Immunoglobulins (Immunoglobulin)IBA 01/2020 - 05/2010
3	Antiviral Agents (Antivirals)IBA 01/2020 - 06/2010
3	Monoclonal AntibodiesIBA 04/2017 - 12/2004
3	LigandsIBA 05/2012 - 06/2010
2	AntigensIBA 01/2019 - 03/2011
1	Granzymes (Granzyme)IBA 12/2021
1	urelumabIBA 12/2021
1	Interleukin-2 (IL2)IBA 12/2021
1	HLA-G Antigens (HLA G)IBA 10/2021
1	Transcription Factors (Transcription Factor)IBA 01/2020
1	CreatinineIBA 01/2019
1	Tyrosine Kinase InhibitorsIBA 01/2017
1	LuciferasesIBA 01/2017
1	Estrogen ReceptorsIBA 01/2017
1	human ERBB2 proteinIBA 01/2017
1	Dihydrotachysterol (AT 10)IBA 03/2015
1	C-Reactive ProteinIBA 11/2013
1	Pattern Recognition ReceptorsIBA 01/2013
1	Interleukin-6 (Interleukin 6)IBA 10/2011
1	Interleukin-10 (Interleukin 10)IBA 10/2011
1	Interleukin-12 (IL 12)IBA 10/2011
1	HLA-DRB1 Chains (HLA DRB1)IBA 03/2011
1	PerforinIBA 11/2010
1	NK Cell Lectin-Like Receptor Subfamily KIBA 06/2010
1	beta-N-AcetylhexosaminidasesIBA 01/2007
1	Interleukin-2 Receptor alpha SubunitIBA 07/2005
1	CalcineurinIBA 05/2005
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 05/2005
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2004
1	EcdysoneIBA 10/2003
1	ecdysone receptorIBA 10/2003
1	Serotonin (5 Hydroxytryptamine)IBA 04/2002
1	Tyrosine (L-Tyrosine)FDA Link 04/2002

Therapy/Procedure

4	Immunotherapy 12/2021 - 04/2016
2	Kidney Transplantation 10/2021 - 01/2017
1	Neoadjuvant Therapy 01/2024
1	Transplantation 12/2023
1	Therapeutics 01/2017
1	Organ Transplantation 01/2017